incubation time, enabled automatic fluid flow with capillary force,
and applied fluorescent dyes as labels for a quantitative analysis.
As a result, it obtained 1 ng/mL CRP sensitivity in human serum
that is good for detecting myocardial infarction. The use of PDMS
substrate may hinder its commercialization due to a difficulty in
mass production [36–38]. Analytical results from a whole blood
sample and the stability of capture antibodies and hydrophilic surface
modification might need to be further explored and characterized
for the full evaluation of its performance.
Wang et al. at Caltech presented a capillary flow microfluidic
lab-on-a-chip to detect multiple target proteins from 7 lL of whole
blood as shown in Fig. 3(b) [39]