This study outlines the chemical characterisation of a large number of commercial spray paints as used in street art, graffiti vandalism and for decoration purposes. The analyses were focused on the identification of the synthetic binding media, pigments and additives such as plasticisers and fillers, providing a database as well as a methodology which could remarkably help investigations in a broad panorama of case studies, ranging from forensic science to cultural heritage. A protocol has been developed based on a multi-technique approach. In particular, Fourier Transform Infrared (FTIR) spectroscopy, Pyrolysis/Gas Chromatography–Mass Spectrometry (Py/GC–MS) and μ-Raman spectroscopy were applied and their strength and weakness points as to the identification of all spray paints components are outlined.