The spectrofluorometric determination of diclofenac
[2-(2%,6%-dichloroanilino)-phenylacetic
acid] in pharmaceutical tablets and ointments is
described. It involves excitation at 287 nm of an
acid solution (HCl 0.01 N) of the drug, and
measurement of the fluorescence intensity at 362
nm. The linear range is 0.2–5.0 mg l1. No
interference is observed from the excipients or
from other drugs which accompany diclofenac in
certain formulations (paracetamol or
cianocobalamine).