Honey has been long utilised as a topical antimicrobial treatment for wound infection, with licensed medical products becoming available in the 1990’s. Whilst often still used as a last line treatment when other therapies have failed, manuka honey is broad spectrum with potent bactericidal activity. Some of the bacterial cellular targets for manuka honey are now known and more continue to be identified. For Gram positive organisms the primary mode of action is to disrupt the cell cycle leading to aberrant cell division and weakening of the cell wall; this is combined with an up-regulation of the general stress response [1,2]. In Gram negative organisms, particularly