Splenomegaly and, less commonly, hepatomegaly are frequently found. Due to the increased
hemolysis, there is also a higher incidence of gallstones, reported in 15–34%[26,27]. A less common
complication is the development of postsplenectomy thrombosis, particularly deep vein thrombosis,
frequently involving the portal vein[28]. It is thought that the postsplenectomy thrombocytosis and
intravascular hemolysis, a prominent feature of this form of thalassemia, contribute to the
hypercoagulable state and thrombus formation. It is therefore recommended to use an anticoagulant in
patients immediately following surgery and to proceed with long-term prophylaxis