Curcumin decreased the expression of transforming
growth factor-b (TGF-b) and extracellular matrix in keloid
fibroblasts suggesting their utility in the treatment of keloids, a
fibrotic disease of the skin characterized by skin overgrowth
[29]. Scleroderma is another fibrotic disease of the skin and
curcumin may exert antifibrotic effect [30] for managing sclerodema
by mechanisms involving suppressing TGF-b. Vitiligo,
a depigmenting disease of human skin is characterized by
localized loss of melanin from the lesional epidermis [31–33].
It is well established that the restoration of the skin color can
be achieved after the reduction of epidermal H2O2 levels
[34,35]. Turmeric is widely used for wound healing and skin
lightening in Asia [36] and is also known for its antioxidant,
anti-inflammatory, and anticarcinogenic properties [37–39].
Vitilgo treatment by combination therapy using UVB phototherapy
and tetrahydrocurcuminoid (derived from curcuminoid)
was found to be more effective than UVB phototherapy
alone [40].