Differently, Hermeto and colleagues have shown more encouraging results in a large population of severely preterm newborns. In their retrospective study, the authors evaluated the impact of the implementation of a ventilation protocol on respiratory outcomes of very premature infants [23]. By reviewing the clinical course of 301 mechanically ventilated infants, with a birth weight less than 1,250 g, they reported that the implementation of a ventilation protocol, driven by registered respiratory therapists, could significantly reduce the weaning time and duration of mechanical ventilation.