In order to inquire into the persistent underrepresentation of urban minority students in the sciences, this study explored three urban African American students' conceptualizations of school science and media science, with emphases on the representation of science in Crime Scene Investigation (CSI ). Based on the data collected from interviews, classroom observations, student journals, focus groups, concept maps, and artifacts, the study shows that the student participants conceptualize school science as a compilation of observed chemical reactions, utilizing specific laboratory apparatus, and laboratory experiments. The study also shows that student participants conceptualize media science as an accruement of evidence collection, observation, photography, analyses of evidence on and off site, and taking safety precautions. While the student participants did not find school science to be applicable in their daily lives, they believed that they had acquired usable and accurate scientific knowledge from media science. Two major themes emerged from the student participants' voices: student participants' acute awareness of their limited access to the scientific world, and student participants' inadequate accruement of scientific knowledge through school and media science. By attending to the student participants' voices, this study lends support to advocating for and developing culturally responsive pedagogy in science education that will facilitate urban students' active engagement and improve their achievement in science education.