values (D) at week 8 and week 16. Discrete data were evaluated
by Pearson’s Chi-square or Fisher’s Exact test. Two factor
repeated measures analysis of variance (RM-ANOVA) with
multiple comparisons by Bonferroni or Friedman test were
used to assessed the effects of treatment, time, and their
interaction. Independent t-test or ManneWhitney test was
utilized in comparing the effect between 2 groups at each time
point. Paired t-test or Wilcoxon Signed Rank test was applied
to compare the change values after 8 weeks and 16 weeks of
treatment within group. The 2-sided hypothesis was used in
all tests and P < 0.05 was considered statistically significant.