In relation to other skin microrelief parameters, such as skin
smoothness (SEsm), our results showed that the formulations studied
produced a significant improvement in the forearm 3 h after
application, when compared to basal values; after 15 days, however,
only the IPAA containing formulation confirmed the improvement
showing greater and more sustained effects than the vehicle
alone on skin smoothness (Fig. 5E). Face applications only showed
improvements by IPAA 3 h after application; after 15 days, no difference
was found. Dobrev [37] evaluating moisturizers effects on
dry skin arrived at the same conclusions by utilizing a subjective
visual analysis and parameters related to skin microrelief such as
SEsm and Rt.