drugs for Dissolving Gallstones (A) Following its secretion from liver into bile, water-insoluble cholesterol is held in solution in the form of micellar complexes with bile acids and phospholipids. When more cholesterol is secreted than can be emulsified, it precipitates and forms gallstones (cholelithiasis). Precipitated cholesterol can be reincorporated into micelles, provided the cholesterol concentration in bile is below saturation.