Figure 2 proposed mode of action of Sibutral. Sibutral inhibits re-uptake of a number of neuro-transmitter leading to sustained elevated levels in synaptic clefts. Increased levels of noradrenaline affect the dopamine reward circuits and this may reduce the “wanting” for food. Higher levels of serotonin may advance the onset of satiety.
Until recently, the medicament was produced and distributed by Abbott Laboratories. The adverse affects that have led to the recent retrieval from the market are cardiovascular accidents, such as heart attack and stroke. In some cases it may cause renal (kidney) disfunctioning.