Hemodialysis techniques
are based on the ability of molecules to diffuse
across a semipermeable membrane, which allows
adequate clearance of low molecular weight particles.
To increase the clearance of middle-to-large
molecules, synthetic membranes with high water
permeability (high-flux membranes) were introduced
years ago. The anticipated benefit of high-
flux over low-flux hemodialysis on patient survival
was not confirmed in the Hemodialysis (HEMO)
study.3