It was concluded that ethanolic extract of C. asiaticum (L) and lycorine can reduce the AAPH induced erythrocyte hemolysis, lipid/protein per oxidation and cell damage. The ethanolic extract of this plant may be used as a source of natural antioxidants as their crude extracts and lycorine exhibit significant free radical scavenging activity when compared with tocopherol. The results indicate that the different concentration of ethanolic extract of C. asiaticum (L) and lycorine exhibited significant antioxidant activities. The maximum percentage of free radicals activity were observed by C. asiaticum when compared with lycorine, however, tocopherol showed higher free radical scavenging activity than the C. asiaticum and lycorine. Therefore, purpose of the present finding confirmed that ethanolic extract of C. asiaticum (L) and lycorine possibly will have defensive antioxidant and have better application in food and drug products.