The results in table I indicate that Montmorillonite KSF and ammonium chloride showed catalytic
reactivity for Biginelli reaction. Montmorillonite KSF has many advantages such as ease of
handling, low cost and use of an environmentally-friendly catalyst. Montmorillonite KSF could be
recovered by filtration and reused with similar reactivity after washing with hot ethanol or methanol
and heating at 115°C for 6 hours. The results are in agreement with those of Bigi [39]. Indeed,
ammonium chloride seems to be an excellent catalyst for the one-pot, three component, Biginelli