2.5. Statistical analysis
The SEN, SPE, PPV, NPV and accuracy were calculated as
described by Eusebi (2013). The LRþ and LR were calculated
as published by Deeks and Altman (2004), and the
DOR was determined in accordance with Glas et al. (2003).
The partial verification bias for the SEN and SPE was corrected
using the following formula developed by Begg and
Greenes (1983)