Lately, it was found that the safflower L.seeds substances such as lignin and phenol flavonoids (Kim et al, 2007 2008). In addition to prevent fat antioxidants and antimelanogenic the activities of these compounds have been learned from the previous study (Takimoto et, Al, 2001 and potent et al, 2004). In addition to feature their color chalcones created intensive scientific interests due to biological and industrial applications of them, such as bacteria, fungi, insect, anesthesia, anti-inflammatory painkillers and impact (Liu et al, 2001).