This studyaimsatmonitoringandriskassessmentoftrihalomethanes(THMs)suchaschloroform,
bromodichloromethane,dibromochloromethaneandbromoform,inthedrinkingwatersuppliesof
RawalpindiandIslamabad.THMsweremonitoredattwentylocationsinthesetwincitiesusingsolid
phase microextraction-gaschromatography(SPME-GC).TotalconcentrationofTHMswasranged
between21and373 mg/L, whereasbothcitieshadanaveragetotalTHMsconcentrationof142and
260 mg/L,respectively.ChloroformwasfoundasonethemajorcontributortotheTHMsconcentration
(485%). TheoccurrenceofTHMsfollowedthegivenorder:chloroform,bromodichloromethane4dibromochloromethane4bromoform.LifetimecancerriskassessmentofTHMswascarriedoutusing
predictionmodelsviadifferentexposureroutes(ingestion,inhalationanddermal).Anaveragelifetime
cancerriskwasfoundtobe0.74104 and 1.24104 forRawalpindiandIslamabad,respectively.
The numberofexpectedcancercasesperyearcouldreachtwocasesforeachcity.Hazardindexvalues
were foundbelowunityforboththecitiesimplyingthattherewouldbenoconsiderablenon-cancer
risk. Oralingestionwasfoundtobeoneofthemainroutesofexposureforbothtypesofriskwhichwas
followedbyinhalationanddermalroutes.