ConclusionsThe present work explains the role of different pore diameters ofNH2-MS and NH2-SBA-15 host particles on activity of GOD at highloadings of 512.2 and 634 mg/g, respectively. GOD showed a highernormalized absolute activity in NH2-SBA-15, compared to that inNH2-MS. This is because NH2-SBA-15 has a larger pore diameterthan GOD dimensions. Therefore, the latter gets adsorbed mostlyon the internal surface of larger pores in a relatively less aggregatedstate due to higher available surface area than that of NH2-MS. Thusstructural property of NH2-SBA-15 was exploited for improvingglucose sensor performance. At optimized electrode compositions,glucose biosensor with NH2-SBA-15 resulted in a linear range of0.4–13.0 mM glucose, higher than that of only 0.4–3.1 mM obtainedfor NH2-MS, or other electrodes (based on MS and SBA-15 systems)reported in literature.The performance of any glucose sensor (with an enzyme immo-bilized in a porous host) can be improved by tuning the followingstructural and compositional variables: (i) using a base electrodewith a high sensitivity towards H2O2(e.g. a Pt electrode instead ofGCE); (ii) using a host matrix with a large pore diameter (e.g. SBA-15); (iii) dispersing highly electrically conductive Pt, Au nanopar-ticles in host; and (iv) electrode composition in terms of relativequantities of enzyme and host on the electrode surface. The presentwork achieves better performance by addressing points (ii) and (iv)from this list, which can be further implemented for performanceenhancement in other more costly Pt or Au based electrode sensors.