The hypothesis
Based on experimental and hypothetical data, showing that medical/biological gases have many protective effects such as antioxidant, anti-inflammatory, anti-apoptotic, and induction of radioresistance, we hypothesize that similar gases which have been produced by microorganisms (biogases) have those properties and may be used as radiation mitigators/protectors in radiation related approaches such as radiotherapy, radiation accidents and in space missions. This hypothesis is based on the following items: 1) finding the main microorganisms that produce biogas, 2) production of biogas in well enough amounts, 3) biosafety of microorganisms and their products, 4) finding the best route of administration 5) targeting the microorganisms in normal tissues in radiotherapy and 6) genetic manipulation of those microorganisms for high efficiency. In regard to item four, route of administration is dependent on sites that biogas should be used. For example, if the treatment site is GI tract, oral, buccal, and rectal administration may be feasible approaches. Also for other sites, targeting microorganisms can be done. The other remedial approach is to earn and separate bacteria from different sites of human body and do an individualized care. For example, we can separate a specific bacteria from a person GI tract and did any required modification on bacteria and again sent into the GI tract.