Romano et al. gave 120–180 mg iodine as iodised
salt or control daily beginning in the first trimester
to healthy pregnant Italian women (n = 35; median
UIC 31–37 mg/L).22 In the treated group, median
UIC increased threefold and thyroid volume did not
change. In the controls, there was no change in UIC,
but a 16% increase in thyroid volume. Treatment had
no effect on maternal thyroid-stimulating hormone
(TSH). Pedersen et al. randomised pregnant Danish
women (n = 54) to receive either 200 mg iodine/day as
KI solution or no supplement from 17 weeks to term.23
Median UIC increased from 55 mg/L to 90–110 mg/L
in treated group. Maternal thyroid volume increased
16% in the treated group vs. 30% in controls. Maternal
thyroglobulin (Tg) and TSH, and cord Tg were
significantly lower in the treated group. No significant
differences were found between groups comparing
maternal or cord T4, triiodothyronine (T3) and
free (F)T4.