granulation tissue was present by day 4 of vacuum therapy, with decreased edema and bacterial counts. Another study reported results of 21 consecutive patients with high-energy, soft-tissue wounds who underwent vacuum therapy for an average of 19.3 days.12 Bollero et al13 likewise reported rapid granulation tissue formation in 35 patients with lower limb traumatic wounds who underwent vacuum therapy. In another study by Chariker et al7, this method was used in 24 pediatric patients with upper and lower extremity injuries. The duration of vacuum therapy averaged 10 days to primary closure and 17 days for secondary closure. Granulation was noted in all patients by day 4, illustrating the short time needed to produce a healthy, granulating tissue bed. Clare et al14 used NPWT with growth factors in 17 cases of persons with diabetes and vascular insufficiency in their extremities. They accomplished treatment without any need for surgery in 6 cases. - See more at: http://www.woundsresearch.com/article/clinical-experience-use-gauze-based-negative-pressure-wound-therapy#sthash.wwiKMZ58.dpuf