As comes mostly from the upland Himalayan catchments which is connected with the study river at the northern part of Bangladesh (Mitamura et al., 2008). The concentration of Cd (11 g/L in winter and 8 g/L in summer) greatly exceeded the drinking water standard value (5 g/L) (Table 2). The average concentration of Pb in water was 35 and 27 g/L during winter and summer season, respectively, which were higher than the drinking water quality standard. Considering the toxicity reference values (TRV) proposed by USEPA (1999) almost all the heavy metals especially Cr,