In the examination of cardiac muscle histophatologic, many lesions were found. Myocardium underwent multifocal necrosis characterized by the number of empty space within the remains of myosit cells.
Indeed, it is one thing that often occurs in the cardiac by High Pathogenecity Avian influenza (HPAI) H5N1 infection
The necrosis of cardiac cells considerably affect the ability of the heart to pump blood throughout the body. Cardiac failure will reduce blood pressure so that in the level of the arterioles, blood which carries oxygen and nutrients for the tissues of the body organs would be reduced.
The cell will be without oxygen and nutrients will not be able to produce the ATP for the organs. Many essential organs will undergo malfunctions.
The blood supply to the heart through the coronaria artery will decline and this cause necrosis in the cardiac muscle and causes cardiac failure20.
The brain, which is the main organ to coordinate all the organs of the body, would lost a lot of its cells because ischemia that will eventually worsen cardiac failure under the coordination.