With the help of ANOVA test it was found that the base and formulation produced significant (p≤0.05) effects on skin erythema at different time intervals. By applying LSD test it was seen that base produced significant effects at, 6th and 8th week while on the other hand formulation showed significant effects at, 2nd, 4th, 6th and 8th week of study period. With the help of paired sample t-test it was evident that there was significant variation in irritation with respect to base & formulation at 4th and 6th week.