Fracture Risk Reduction
There is acceptable evidence to recommend alendronate, risedronate, zoledronic acid, strontium ranelate and teriparatide for vertebral risk fracture risk reduction in older people. There is significant early onset of benefit (within 12 months) with risedronate, zoledronic acid, strontium ranelate and teriparatide. At three years, there is evidence for sustained benefit with alendronate, risedronate, zoledronic acid and strontium ranelate