His blood sugar started to rise rapidly about 6 hours after injection, which was 2 full hours before his next dose. BG HOURS Figure 6. A sample blood glucose curve where insulin is rapidly metabolized and lacks duration.BG HOURS Figure 6 shows a blood glucose curve that suggests rapid metabolism of insulin, resulting in a lack of duration.Chris generally did well on R. He felt better than he had in a long time with R plus Metacam® for arthritis. But the speed with which he metabolized the insulin continued to be a problem. His starting level was too high and we could not get the highest numbers into a good range without him experiencing dangerously low blood sugar at the nadir (see Figure 7). So we tried adding some NPH insulin to extend the effect