In this
study, we have also evaluated the effect of CFP in indomethacin
incubated aorta rings and in SHR intraperitoneally injected this
inhibitor of the cyclo-oxygenase enzyme and the endothelial prostanoid biosynthesis. However, indomethacin treatment did not
modify SBP in the SHR, and this compound clearly failed to modify
CFP antihypertensive effect.