Saffiano is leather. My SA at MK told me that "saffiano" refers to the leather being stamped in a series of cross-hatch designs which makes the leather virtually scratch resistant and easy to clean. The Saffiano Hamilton, Selma etc. are all leather. Some of the MK small totes have the saffiano effect, but are made of PVC and the MK tag states that it is PVC, not leather. So if in doubt, your best bet is to check the tag!