Abstract Invasive mechanical ventilation is a life-saving procedure which is largely used in neonatal intensive care units, particularly in very premature newborn infants. However, this essential treatment may increase mortality and cause substantial morbidity, including lung or airway injuries unplanned extubations, adverse hemodynamic effects, analgosedative dependency and severe infectious complications, such as ventilator-associated pneumonia. Therefore, limiting the duration of airway intubation and mechanical ventilator support is crucial for the neonatologist, who should aim to a shorter process of discontinuing mechanical ventilation as well as an earlier appreciation of for spontaneous breathing trials. Unfortunately there is scarce information about the best ways to perform an effective weaning process in infants undergoing mechanical ventilation, thus in most weaning course is still based upon the individual judgment of the cases the attending clinician Nonetheless, some evidence indicate that volume targeted ventilation modes are more effective in reducing the duration of mechanical ventilation trilditional pressure limited ventilation modes, particularly in very preterm