Nurses have been identified as the priority group whose preparedness is a critical element in response to the pandemic outbreak situation. Further spread of viruses is a major problem during a pandemic which can be controlled by practicing proper protective measures. For this, efforts should be targeted at educating nurses to improve knowledge and protective responses in the future outbreak of pandemic influenza. This study has revealed important gaps in the staff nurses knowledge as well as some of the malpractices and behaviors towards influenza pandemic which should be addressed in order to control further spread of pandemic influenza.