Two metabolic disorders that can lead to constipation are a high levels of calcium and a low level of thyroid hormones. People with kidney disease or diabetes also tend to have Constipation. In elderly the constipation is usually caused by dehydration; in people of any age, this disorder affects depression. There are medications that can cause constipation: cough syrups, pain medications containing codeine. Some antidepressants, iron supplements, medicines for hypertension and heart, calcium and some antihistamines.