Spanish Rule
New infectious diseases, endemic to the Europeans, caused high fatalities among the Amerindian population during the first decades of Spanish rule, as they had no immunity. At the same time, the natives were forced into the encomienda labor system for the Spanish. In 1563, Quito became the seat of a real audiencia (administrative district) of Spain and part of the Viceroyalty of Peru and later the Viceroyalty of New Granada.