Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-machi,
Syougoin, Sakyou-ku, Kyoto City, Kyoto 606-8507, Japan
2
Department of Plastic and Reconstructive Surgery, Kansai Medical University, 2-5-1 Shin-machi, Hirakata City,
Osaka 573-1010, Japan
3
GUNZE Ltd. QOL Research Center Laboratory, 1 Ishiburo, Inokura Shinmachi, Ayabe, Kyoto 623-8512, Japan
Correspondence should be addressed to Naoki Morimoto; morimotn@hirakata.kmu.ac.jp
Received 5 January 2016; Revised 23 February 2016; Accepted 3 March 2016
Academic Editor: Francesco Piraino
Copyright © 2016 Chizuru Jinno et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The objective of this study was to compare the effectiveness of the collagen-gelatin sponge (CGS) with that of the collagen sponge
(CS) in dermis-like tissue regeneration. CGS, which achieves the sustained release of basic fibroblast growth factor (bFGF), is a
promising material in wound healing. In the present study, we evaluated and compared CGSs and conventional CSs. We prepared
8 mm full-thickness skin defects on the backs of rats. Either CGSs or CSs were impregnated with normal saline solution (NSS) or
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