Psoriasis vulgaris is a chronic autoimmune,
inflammatory and proliferative skin disease. Recently,
there is a need for new methods to detect and to monitor
this dermatological syndrome at any stage. The application
of differential scanning calorimetry (DSC) should be as a
new diagnostic method for psoriasis detection and monitoring
using human plasma. We aimed to detect blood
plasma components with DSC in psoriasis patients. The
study included 18 white adults (eight men and ten women;
median age 55.7 years) who had underwent a full skin
examination for psoriasis. According to the psoriasis area
severity index (PASI) we selected them into three groups:
PASI: 0 (symptomless), PASI: 1–6 (minimal symptoms),
PASI: [7 (symptoms). According to medical treatment
human blood plasma samples were collected from healthy
controls, patients without or with therapy, and were analyzed
by DSC technique. In this preliminary study we
observed that thermal changes (Tm, calorimetric enthalpy)
in blood plasma showed closed correlation with psoriasis
severity and medical treatment. Further studies are needed
to elucidate these relationships, but our application of the
DSC method has provided a potential new tool for the early
diagnosis and monitoring of psoriasis patients.