In summary, the homogeneous catalysis of LS in IL was successfully utilized as an efficient and environmentally friendly system for the conversion of xylose to furfural. The conversion yield of furfural from xylose was up to 21.0% for 1.5 h under mild conditions. LS was stable in the reaction process. The reusability study of the LS−IL catalytic system illustrated that the furfural yield decreased from 21.0 to 15.1% after five cycles, and the catalytic activity could be recovered after removal of the accumulated humins. For the integration of using sustainable lignocelluloses, renewable catalyst, and environmentally friendly solvent, this study shows a promising furfural production process that followed the concept of green chemistry.