5:00the renin-angiotensin system is a feedback loop it is going to try to
5:04maintain and normal
5:05amount of blood pressure and the body and the kidney is responding the kidney
5:10is the thing that is sensing this in responding to the situation
5:13so the vasculature and kidney is kinda looking at how much blood pressures down
5:17there and saying hey not enough blood pressure
5:19let's kick it up so it produces ran in rain and then gets converted from
5:23angiotensin 1 and then test back to the lawn which gets converted and she jets
5:28into
5:28and then it has an effect on the patient's
5:31blood pressure
5:38aldosterone is produced by the adrenal glands to help regulate sodium
5:43it's also stimulated by the renin-angiotensin system and it tells
5:47the kidneys to hang onto
5:49fluid so this is another mechanism by which the body is trying to hang onto
5:54fluid
5:55if we happen to have a situation where we are dehydrated
5:58so dehydrated situations out Astros gonna be produced to tell the body to
6:02hang onto fluid
6:04now are natural peptides on the other hand there primarily used
6:08to try to get rid of fluid in situations where the patients too much fluid on
6:11board
6:12so it's going to stimulate our water and sodium excretion
6:16and again these are coming from the heart when the heart is being stretched
6:20too much
6:21we have two main ones who were looking at HO naturally peptide
6:25and brain X-rated peptide now the npr brain natural peptide does not come
6:31from the brain what would you think so the name says
6:35brain I mean come on but instead it comes from the heart
6:39so why is it that we caught brain naturally have tied
6:42well was first isolated from the brains of animals and that's where the
6:47terminology came from
6:48however in a human body BNP comes from the heart
6:52and it's going to be the result of having the heart stretch too much
6:56because we have too much blood volume on board BNP then goes down it tells the
7:00kidney take get rid December this fluid were being overly stretche