Rice grains are complex matrices, leading to difficulties in the applications of the various multi-residue methods described in the literature (Pareja, Fernández-Alba, Cesio, & Heinzen, 2011).
The selectivity of MISPE for five SUHs in the clean-up of rice grain samples prior to RP-HPLC was evaluated.
According to the optimised procedure of MISPE described above, n-hexane was applied as the loading solvent and the washing solvent, followed by the extraction with methanol/acetic acid (9:1, v/v).