AAbstractObjective: to investigate the effect of vitamin A supplementation on the retinol concentrationin colostrum under fasting and postprandial conditions.Methods: this was a quasi-experimental study, with before and after assessments, conductedwith 33 patients treated at a public maternity hospital. Blood and colostrum samples werecollected under fasting conditions in the immediate postpartum period. A second colostrum col-lection occurred two hours after the first meal of the day, at which time a mega dose of 200,000IU of retinyl palmitate was administered. On the following day, the colostrum was collectedagain under fasting and postprandial conditions. Serum and colostrum retinol concentrationswere determined by high performance liquid chromatography.Results: the serum retinol concentration was 37.3 (16.8-62.2) g/dL, indicating adequatenutritional status. The colostrum retinol concentration before supplementation was 46.8 (29.7-158.9) g/dL in fasting and 67.3 (31.1-148.7) g/dL in postprandial condition (p < 0.05), showingan increase of 43.8%. After supplementation, the values were 89.5 (32.9-264.2) g/dL and 102.7(37.3-378.3) g/dL in fasting and postprandial conditions, respectively (p < 0.05), representingan increase of 14.7%.Conclusions: this study demonstrated that maternal supplementation with high doses of vitaminA in postpartum resulted in a significant increase of the retinol concentration in colostrum underfasting conditions, with an even greater increase after a meal.© 2014 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.
AAbstractObjective: to investigate the effect of vitamin A supplementation on the retinol concentrationin colostrum under fasting and postprandial conditions.Methods: this was a quasi-experimental study, with before and after assessments, conductedwith 33 patients treated at a public maternity hospital. Blood and colostrum samples werecollected under fasting conditions in the immediate postpartum period. A second colostrum col-lection occurred two hours after the first meal of the day, at which time a mega dose of 200,000IU of retinyl palmitate was administered. On the following day, the colostrum was collectedagain under fasting and postprandial conditions. Serum and colostrum retinol concentrationswere determined by high performance liquid chromatography.Results: the serum retinol concentration was 37.3 (16.8-62.2) g/dL, indicating adequatenutritional status. The colostrum retinol concentration before supplementation was 46.8 (29.7-158.9) g/dL in fasting and 67.3 (31.1-148.7) g/dL in postprandial condition (p < 0.05), showingan increase of 43.8%. After supplementation, the values were 89.5 (32.9-264.2) g/dL and 102.7(37.3-378.3) g/dL in fasting and postprandial conditions, respectively (p < 0.05), representingan increase of 14.7%.Conclusions: this study demonstrated that maternal supplementation with high doses of vitaminA in postpartum resulted in a significant increase of the retinol concentration in colostrum underfasting conditions, with an even greater increase after a meal.© 2014 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.
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