Fewer patients in the combination-therapy group than in the monotherapy group were able to reach the full target dose of lisinopril or placebo (589 vs. 629); 89.6% of the patients in the combination-therapy group and 93.4% of the patients in the monotherapy group were taking at least 10 mg of lisinopril or placebo per day at the end of the dose-adjustment period. At the end of the study, 83.9% of patients in the monotherapy group and 79.3% of patients in the combination-therapy group were taking at least 10 mg of lisinopril or placebo per day.