Methanolic extracts of A. paniculata as well as chloroform and hexane extracts were reported to inhibit the growth of bacterial and fungal pathogens (Bobbarala et al. 2009). The aqueous extract of A. paniculata against anti-HIV was ruled out by testing the inhibitory activities against HIV in the H9 cell line (Chao & Lin 2010). A phase I doseescalating clinical trial of andrographolide in HIV positive patients reported a significant rise in the mean CD4+ lymphocyte level of HIV patients. Andrographolide inhibited HIV-induced cell cycle disregulation, leading to a rise in CD4+ lymphocyte levels in HIV-1 infected individuals (Calabrase et al. 2000). Andrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide