A fundamental issue concerns the minimal effective dosage
of exercise needed to improve depression. Dunn,
Trivedi, Kampert, Clark, Chambliss studied the doseresponse
relation of exercise and reduction in depressive
symptoms in patients with mild to moderate major depression
who exercised individually [36]. They found that individuals
who exercised according to the public health recommendations,
3-5 times a week with a weekly energy expenditure
of 17.5 kcal/kg/week, had significantly larger reductions
in depression compared to those who exercised with low
intensity and a weekly energy expenditure of 7
kcal/kg/week. The latter regimen had results comparable to a
placebo condition with stretching and flexibility exercise.
After 12 weeks exercise according to the public health recommendations,
the Hamilton Rating Scale for Depression
(HRSD) scores were reduced 47% from baseline. Forty-six
percent of participants in the public health recommendations
group had a therapeutic response to treatment, defined as a
50% reduction in baseline HRSD, and 42% of this group had
remission of symptoms, defined as an HRSD score < 7. The
researchers concluded that aerobic exercise, according to the
public health recommendations, was effective in treating
mild to moderate major depression. The rates of response
and remission were comparable to the rates reported in trials
of cognitive behavioural therapy, antidepressant medication,
and other exercise studies.
A fundamental issue concerns the minimal effective dosageof exercise needed to improve depression. Dunn,Trivedi, Kampert, Clark, Chambliss studied the doseresponserelation of exercise and reduction in depressivesymptoms in patients with mild to moderate major depressionwho exercised individually [36]. They found that individualswho exercised according to the public health recommendations,3-5 times a week with a weekly energy expenditureof 17.5 kcal/kg/week, had significantly larger reductionsin depression compared to those who exercised with lowintensity and a weekly energy expenditure of 7kcal/kg/week. The latter regimen had results comparable to aplacebo condition with stretching and flexibility exercise.After 12 weeks exercise according to the public health recommendations,the Hamilton Rating Scale for Depression(HRSD) scores were reduced 47% from baseline. Forty-sixpercent of participants in the public health recommendationsgroup had a therapeutic response to treatment, defined as a50% reduction in baseline HRSD, and 42% of this group hadremission of symptoms, defined as an HRSD score < 7. Theresearchers concluded that aerobic exercise, according to thepublic health recommendations, was effective in treatingmild to moderate major depression. The rates of responseand remission were comparable to the rates reported in trialsof cognitive behavioural therapy, antidepressant medication,and other exercise studies.
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