It was often reported that the adoption of R410A could bring benefits for A/C or heat pumps [1–4], but no in-depth comparative studies have been conducted between R410A and R22 residential A/C from the aspects of the system performance, energy saving and the environmental impact. In order to obtain reasonable comparison results, the A/C to be compared should be comparable firstly, which was neglected in previous relevant reports by Spatz [2] and Shen [3]. Therefore, in this technical article, four comparable typical residential R410A and R22 A/C common in Asia market will be developed and their detailed comparison results will be presented to demonstrate the benefits of R410A.