In another study
[8], we determined the photoprotective effects of resveratrol
against multiple UVB exposure-mediated damages to the skin of SKH-1 hairless mouse. Our data demonstrated that a topical preapplication
of resveratrol (10 lmol/0.2 ml/mouse) 30 min prior to
UVB exposures (180 mJ/cm2 7 exposures on alternate days) to
mouse skin resulted in a significant decrease in UVB-mediated increases
(i) in skin edema and hyperplasia, (ii) infiltration of leukocytes
into the epidermis and dermis, and (iii) protein levels of
PCNA in epidermis