Many of the psychiatric-focused studies have focused on
depression by itself and in combination with other conditions
such as HIV and aging. Most interventions have focused on
unidimensional factors (i.e., patient-related factors). However,
as discussed above, many other factors affect patient
adherence. For that reason, multidimensional interventions
that also target the cultural, socioeconomic, health-system,
and provider barriers that influence adherence are required.
Although these multidimensional approaches have shown
the best results, their use is limited because they are labor
intensive and costly.