Stress is crucially related to the pathophysiology of mood disorders. One of the key adaptive responses to stress involves stimulation of hypothalamic–pituitary–adrenal (HPA) axis releasing glucocorticoids (GCs) (cortisol in humans and corticosterone (CORT) in rodents) to the systemic circulation [1]. GCs elicit a spectrum of physiologic changes that help the organism deal with an acute stressor in an effective manner. However, excessive release of GCs can promote psychological dysfunctions such as depression and anxiety [1