The study of DNA damage at the chromosomal level and micronuclei formation is a vital part of genetic toxicity screening.
The in vitro CA and MN assay was carried out with KalmColdTM using CHO-K1 cells.
KalmColdTM did not induce significant chromosome aberrations and micronuclei formation in CHO-K1 cells in vitro.
While going through the published scientific information on A. paniculata, we came across the study undertaken by Avani and Rao (2008) which aimed at evaluating the protective role of A. paniculata extract on arsenic induced genotoxicity.
Here A. paniculata extract was tested at a single concentration (0.01 lg/7 ml culture media) against different concentrations of arsenic.
Their results elucidated that 0.01 lg/7 ml of A. paniculata extract did not induce chromosomal aberrations in peripheral
blood lymphocytes and also moderately diminished the arsenic induced clastogenicity