A combined spinal epidural technique for abdominal hysterectomy proved to be a better mode of anaesthesia as it offers the flexibility of achieving a desired level of sensory and motor block. The synergistic effect of combining ketamine with morphine epidurally had provided good analgesia and facilitated early mobilization. The side effects like nausea, vomiting and sedation were minimal in the group comprising of morphine 30mcg kg-1 with ketamine 0.25mg kg-1 . To conclude this clinical study, we found that morphine 30mcg kg-1 with ketamine 0.25mg kg-1 is the ideal combination, as it provides effective analgesia as well as early mobilisation without causing much side effects like nausea, vomiting and sedation.