In a randomized comparative trial conducted on 99 children who are febrile aged 6 months to 12 years, the mean tympanic temperature in the combined paracetamol and ibuprofen
group was significantly lower compared with the paracetamol
group 4 hours after drug administration (mean reduction in
temperature 2.19 ± 0.83 vs 1.48 ± 0.94; P < .05)