Avian influenza (AI) is a highly contagious viral disease affecting several species of birds used for food (chickens, turkeys, quails, guinea fowl, etc.), pet birds and wild birds (5). The AI viruses are orthomyxoviruses, influenza type A and exhibit high frequency of genetic resortment with resultant antigenic changes in the viral surface glycoproteins. This makes influenza virusesformidable challenge for control efforts (6). Highly pathogenic AI viruses of the H5N1 subtypes are zoonotic agents that present a continuing threat to animal and human health (7). Avian influenza (H5N1) outbreak was first in Nigeria in the year 2006 (8), since then the disease has been ravaging poultry farms in the country.Humans can contact AI virus through direct contact with bird faeces and respiratory secretions, droplets and by mechanical transfer through contacts with contaminationated formites (9). Depending on environmental conditions, AI viruses may remain infectious in manure, water, soil and contaminated equipments for at least 35 days and perhaps as long as 3 months in colder climates (9). The serious pandemic threat posed by AI H5N1 intensified the urgency of global pandemic preparedness for influenza H5N1 (10).The objective of this study is to assess the physical and psychological ill-health of vegetable workers that make use of poultry manure and their awareness of AI pandemic threat.